Cure of Overdose Therapy of overdosage is pushed by the overall clinical presentation, and contains discontinuation of Promethazine HCl and Codeine Phosphate Oral Resolution together with establishment of acceptable therapy. Give primary notice for the reestablishment of satisfactory respiratory Trade via provision of a patent and guarded airway as well as the establishment of assisted or controlled air flow.

Promethazine has an elimination 50 percent-lifetime of 10-14 hrs, with excretion of metabolites appearing within the urine and feces. The sulfoxides of promethazine and N-demethylpromethazine would be the predominant metabolites appearing during the urine.

eight.six Renal Impairment The pharmacokinetics of Promethazine HCl and Codeine Phosphate Oral Alternative hasn't been characterized in people with renal impairment. Codeine pharmacokinetics might be altered in patients with renal failure. Clearance could be diminished and the metabolites might accumulate to much larger plasma stages in individuals with renal failure compared to sufferers with usual renal operate.

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In Females with ordinary codeine metabolism (normal CYP2D6 action), the level of codeine secreted into human milk is low and dose-dependent. There is absolutely no info on the consequences of the codeine on milk production.

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An overdose is often a healthcare crisis, so seek out support without delay when you or somebody else encounters these signs.

Promethazine HCl and Codeine Phosphate Oral Remedy is indicated for your temporary aid of coughs and upper respiratory signs connected with allergy or even the frequent chilly in patients 18 several years of age and older.

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